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Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 667-685 doi: 10.1007/s11684-022-0960-z

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and a commoncause of liver cirrhosis and cancer.the therapeutic potential of A. muciniphila for NAFLD, especially in the inflammatory stage, nonalcoholic

Keywords： Akkermansia muciniphila     NAFLD     NASH     steatosis     inflammation    

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miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 389-396 doi: 10.1007/s11684-016-0468-5

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver cirrhosis and hepatocellular carcinomagene expression, and the dysregulation of miRNAs is involved in various biological processes in the livermiRNAs and NAFLD progression and have shown that circulating miRNAs reflect histological changes in the liver

Keywords： nonalcoholic fatty liver disease     nonalcoholic steatohepatitis     hepatocellular carcinoma     miRNA    

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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract:

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simplesteatosis to advanced pathologies, including nonalcoholic steatohepatitis and cirrhosis.steatosis, which is characterized by excessive accumulation of triglyceride-rich lipid droplets in the liverAccumulating evidence supports that dysregulation of adipose lipolysis and liver de novo&

Keywords： nonalcoholic fatty liver disease     insulin resistance     obesity    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the livernatural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liverdiseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma.and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholicliver disease     nonalcoholic fatty liver disease     hepatocellular carcinoma    

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Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system

ZHOU Guangde, ZHAO Jingmin, DING Xiaohui, PAN Deng, SUN Yanling, YANG Jianfa, ZHAO Yulai

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 413-417 doi: 10.1007/s11684-007-0081-8

Abstract: To summarize the pathological features of nonalcoholic liver disease (NAFLD) in China based on a histologicaldesigned by the Pathology Committee of NASH Clinical Research Network (NASH-CRN), the specimens of liversteatosis, lobular inflammation, hepatocytic ballooning and fibrosis were presented widespread in NAFLD liverThe number of megamitochondria is more frequently be found in NAFLD, while in alcoholic liver diseases
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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposedWe aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liverdisease (NAFLD), with the progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuriacriteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fattyliver patients.

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 460-471 doi: 10.1007/s11684-021-0861-6

Abstract: Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistanceThis pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis

Keywords： low-carbohydrate diet     obesity     nonalcoholic fatty liver disease     continuous glucose monitoring     mean    

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Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fattyliver disease: a translational approach

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: been investigated in basic studies, with satisfactory effects on insulin resistance in non-alcoholic fattyliver disease (NAFLD).

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled    

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Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 288-293 doi: 10.1007/s11684-011-0127-9

Abstract: Haemorheological abnormalities have been described in diabetes mellitus, as well as in non-alcoholic fattyliver disease (NAFLD).However, the relationship between the changes in liver fat content and haemorheology is unknown.IHLC was quantified using proton magnetic resonance spectroscopy ( H-MRS) scanning of the liver.In summary, haemorheological disorders are linked to non-alcoholic fatty liver in type 2 diabetes.

Keywords： diabetes mellitus     type 2     haemorheology     non-alcoholic fatty liver disease    

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The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Engineering 2017, Volume 3, Issue 1,   Pages 110-114 doi: 10.1016/J.ENG.2017.01.017

Abstract: microbiota are instrumental in determining the occurrence and progression of hepatocarcinoma, chronic liverdiseases related to alcohol, nonalcoholic fatty liver disease (NAFLD), and cirrhosis.As far as disease management is concerned, probiotics may provide a novel direction for therapeuticsHere, we provide an overview of the relationships among the gut microbiota, tumors, and liver diseases

Keywords： Gut microbiota     Dysbiosis     Tumorigenesis     Hepatocellular carcinoma     Nonalcoholic fatty liver disease    

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γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 262-268 doi: 10.1007/s11684-017-0584-x

Abstract: γδ T cells are enriched in the liver and exhibit liver-specific features.fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regenerationWe believe that determining the properties and functions of γδ T cells in liver diseasesenhances our understanding of the pathogenesis of liver diseases and is useful for the design of novelγδ T cell-based therapeutic regimens for liver diseases.

Keywords： γδT cells     liver infection     non-alcoholic fatty liver disease     autoimmune hepatitis     liver fibrosis and cirrhosis     liver cancer     liver regeneration    

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases currently in thecontext of obesity worldwide, which contains a spectrum of chronic liver diseases, including hepaticaddition to the classical “Two-hit” theory, NAFLD has been recognized as a typical gut microbiota-related diseasebecause of the intricate role of gut microbiota in maintaining human health and disease formation.Moreover, gut microbiota is even regarded as a “metabolic organ” that play complementary roles to that of liver

Keywords： gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

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An Update on the Efficacy and Functionality of Probiotics for the Treatment of Non-Alcoholic Fatty LiverDisease Article

Mingfei Yao, Lingling Qv, Yanmeng Lu, Baohong Wang, Björn Berglund, Lanjuan Li

Engineering 2021, Volume 7, Issue 5,   Pages 679-686 doi: 10.1016/j.eng.2020.01.017

Abstract:

Non-alcoholic fatty liver disease (NAFLD), which has a global prevalence of 20%–33%, has becomethe main cause of chronic liver disease.The mechanisms by which probiotics directly or indirectly affect the disease are illustrated, based on

Keywords： Non-alcoholic fatty liver disease (NAFLD)     Gut microbiota     Probiotics     Next-generation probiotics (NGPs    

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decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 363-367 doi: 10.1007/s11684-009-0064-z

Abstract: decoction on CD14 expression in the lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats.disease, and 25 of these 50 rats were treated with decoction simultaneously.Liver injury was evaluated by biochemical examination.decoction pretreatment significantly protected against acute alcohol-induced liver injury, which was

Keywords： liver disease     alcohol     Zhihuang decoction     CD14     signal transduction    

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Graft versus host disease after liver transplantation: A case report

Peng-Ji GAO, Xi-Sheng LENG, Dong WANG, Guang-Ming LI, Lei HUANG, Jie GAO, JI-Ye ZHU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 469-472 doi: 10.1007/s11684-010-0120-8

Abstract: In documenting clinical experience in the diagnosis and treatment of graft host disease (GVHD), we retrospectivelyanalyzed data of one case that has developed GVHD after liver transplantation.This patient exhibited fever, skin rash, and diarrhea on day 9 after liver transplantation.His liver function was normal.suggests that reducing the dosage of immunosuppressive agents can be an effective strategy for GVHD after liver

Keywords： liver transplantation     graft versus host disease    

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Title Author Date Type Operation

Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Journal Article

miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Journal Article

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system

ZHOU Guangde, ZHAO Jingmin, DING Xiaohui, PAN Deng, SUN Yanling, YANG Jianfa, ZHAO Yulai

Journal Article

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Journal Article

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

Journal Article

Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fattyliver disease: a translational approach

Journal Article

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Journal Article

The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Journal Article

γδ T cells in liver diseases

Xuefu Wang, Zhigang Tian

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

An Update on the Efficacy and Functionality of Probiotics for the Treatment of Non-Alcoholic Fatty LiverDisease

Mingfei Yao, Lingling Qv, Yanmeng Lu, Baohong Wang, Björn Berglund, Lanjuan Li

Journal Article

decoction on CD14 expression in lipopolysaccharide signal transduction pathway of alcohol-induced liverdisease in rats

Rui ZHU MD , Lin SHEN MD , Jianguo LIU MD , Weili ZHANG MM , Ling YANG MD ,

Journal Article

Graft versus host disease after liver transplantation: A case report

Peng-Ji GAO, Xi-Sheng LENG, Dong WANG, Guang-Ming LI, Lei HUANG, Jie GAO, JI-Ye ZHU,

Journal Article